Jürgen Scheller Selected Research

Rheumatoid Arthritis

12/2021	Exclusive inhibition of IL-6 trans-signaling by soluble gp130FlyRFc.
4/2014	A rice-based soluble form of a murine TNF-specific llama variable domain of heavy-chain antibody suppresses collagen-induced arthritis in mice.
2/2014	Interleukin-6: from basic biology to selective blockade of pro-inflammatory activities.
2/2013	Recombinant IL-6 treatment protects mice from organ specific autoimmune disease by IL-6 classical signalling-dependent IL-1ra induction.
6/2011	The soluble Interleukin 6 receptor: generation and role in inflammation and cancer.
3/2011	Essential role of neutrophil mobilization in concanavalin A-induced hepatitis is based on classic IL-6 signaling but not on IL-6 trans-signaling.
1/2011	ELPylated anti-human TNF therapeutic single-domain antibodies for prevention of lethal septic shock.
6/2009	Transglutaminase-catalyzed covalent multimerization of Camelidae anti-human TNF single domain antibodies improves neutralizing activity.
9/2006	Functional expression of a biologically active fragment of soluble gp130 as an ELP-fusion protein in transgenic plants: purification via inverse transition cycling.
8/2006	Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer.

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Jürgen Scheller Research Topics

Disease

26	Inflammation (Inflammations) 01/2021 - 08/2006
20	Neoplasms (Cancer) 12/2021 - 08/2006
12	Autoimmune Diseases (Autoimmune Disease) 12/2021 - 05/2007
12	Rheumatoid Arthritis 12/2021 - 01/2005
10	Infections 01/2022 - 01/2005
8	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 12/2021 - 08/2006
7	Colonic Neoplasms (Colon Cancer) 02/2014 - 01/2005
6	Crohn Disease (Crohn's Disease) 12/2021 - 01/2005
5	Myocardial Infarction 01/2017 - 10/2010
5	Colitis 09/2014 - 08/2007
5	Peritonitis 02/2014 - 01/2005
4	Ischemia 11/2018 - 09/2014
3	Arthritis (Polyarthritis) 01/2019 - 01/2009
3	Infarction (Infarctions) 11/2018 - 01/2014
3	Asthma (Bronchial Asthma) 02/2016 - 08/2006
3	Kaposi Sarcoma (Kaposi's Sarcoma) 06/2011 - 09/2006
2	Tuberculosis (Tuberculoses) 01/2017 - 10/2012
2	Carcinogenesis 02/2016 - 02/2009
2	Sepsis (Septicemia) 11/2015 - 06/2011
2	Reperfusion Injury 10/2015 - 09/2014
2	Hypertension (High Blood Pressure) 12/2014 - 07/2007
2	Psoriasis (Pustulosis Palmaris et Plantaris) 12/2014 - 01/2011
2	Neurodegenerative Diseases (Neurodegenerative Disease) 06/2014 - 02/2014
2	Atherosclerosis 02/2014 - 07/2012
2	Liver Cell Adenoma (Hepatocellular Adenoma) 04/2012 - 08/2010
2	Hepatocellular Carcinoma (Hepatoma) 09/2006 - 09/2006
1	Virus Diseases (Viral Diseases) 01/2022
1	COVID-19 01/2022
1	Cytokine Release Syndrome 01/2022
1	Ulcerative Colitis 12/2021
1	Hemorrhage 01/2021
1	Thrombocytopenia (Thrombopenia) 01/2021
1	Liver Diseases (Liver Disease) 01/2021
1	Liver Cirrhosis (Hepatic Cirrhosis) 10/2019
1	Pneumonia (Pneumonitis) 01/2017
1	Ventricular Remodeling 10/2016
1	Carcinoma (Carcinomatosis) 02/2016
1	Sleep Deprivation 11/2015
1	Lupus Nephritis 07/2015
1	Nephritis 07/2015
1	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 12/2014
1	Skin Diseases (Skin Disease) 12/2014
1	Cicatrix (Scar) 09/2014
1	Coronary Disease (Coronary Heart Disease) 09/2014
1	Myocardial Ischemia (Ischemic Heart Diseases) 09/2014
1	Body Weight (Weight, Body) 06/2014
1	Large Granular Lymphocytic Leukemia 04/2014
1	Abscess 03/2014
1	Pancreatitis 02/2014
1	Pancreatic Neoplasms (Pancreatic Cancer) 02/2014
1	Ovarian Neoplasms (Ovarian Cancer) 02/2014

Drug/Important Bio-Agent (IBA)

46	Interleukin-6 (Interleukin 6)IBA 01/2022 - 05/2005
27	CytokinesIBA 12/2021 - 01/2005
10	Proteins (Proteins, Gene)FDA Link 01/2022 - 09/2006
10	Interleukin-6 Receptors (Interleukin 6 Receptor)IBA 01/2022 - 09/2006
6	Cytokine Receptor gp130IBA 01/2022 - 01/2005
6	InterleukinsIBA 12/2021 - 09/2006
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 09/2014 - 06/2009
3	olamkiceptIBA 12/2021 - 06/2011
3	Interleukin-11 (Interleukin 11)IBA 12/2021 - 04/2012
3	ChemokinesIBA 01/2021 - 09/2010
3	Interleukin-23 (Interleukin 23)IBA 11/2018 - 10/2015
3	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA 01/2014 - 09/2006
2	Monoclonal AntibodiesIBA 01/2022 - 09/2014
2	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2021 - 12/2009
2	Hyaluronic Acid (Hyaluronan)IBA 11/2018 - 01/2014
2	Metalloproteases (Metalloproteinases)IBA 11/2016 - 08/2010
2	Dextrans (Dextran)FDA Link 09/2014 - 02/2010
2	sodium sulfate (sodium bisulfate)FDA LinkGeneric 09/2014 - 02/2010
2	CollagenIBA 09/2014 - 10/2010
2	Phosphotransferases (Kinase)IBA 04/2014 - 07/2013
2	LigandsIBA 04/2012 - 08/2010
2	Interleukin-27 (Interleukin 27)IBA 12/2007 - 01/2005
1	Bispecific AntibodiesIBA 01/2022
1	Bile Acids and Salts (Bile Acids)IBA 01/2021
1	Sirtuin 3IBA 01/2020
1	SirtuinsIBA 01/2020
1	NAD (NADH)IBA 01/2020
1	Etanercept (Enbrel)FDA Link 10/2019
1	TenascinIBA 01/2017
1	AerosolsIBA 01/2017
1	Adenosine (Adenocard)FDA LinkGeneric 01/2017
1	EnzymesIBA 01/2017
1	ConnectinIBA 10/2016
1	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 11/2015
1	Acute-Phase Proteins (Acute-Phase Protein)IBA 10/2015
1	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2014
1	Peroxidase (Myeloperoxidase)IBA 12/2014
1	Interleukin-17 (Interleukin 17)IBA 12/2014
1	Interleukin-1 (Interleukin 1)IBA 09/2014
1	phospholipase D1IBA 09/2014
1	C-Reactive ProteinIBA 09/2014
1	Transforming Growth Factors (Transforming Growth Factor)IBA 09/2014
1	Ciliary Neurotrophic Factor (CNTF)IBA 06/2014
1	Nerve Growth Factors (Neurotrophins)IBA 06/2014
1	src-Family KinasesIBA 04/2014
1	Pharmaceutical PreparationsIBA 02/2014
1	CarbohydratesIBA 01/2014

Therapy/Procedure

9	Therapeutics 01/2022 - 05/2007
3	Ligation 10/2019 - 06/2011